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Reported by Jules Levin CROI 2011 Boston Andrea Antinori1, Patrizia Lorenzini1, Maria Letizia Giancola1, Giovanna Picchi1, Francesco Baldini1, Laura Monno2, Adriana Ammassari1, Antonella d'Arminio Monforte3, Paola Cinque4, Valerio Tozzi1 1National Institute for Infectious Diseases "Lazzaro Spallanzani", IRCCS, Rome, Italy; 2University of Bari, Italy; 3San Paolo Hospital, University of Milan, Italy; 4HSR San Raffaele Scientific Institute, Milan, italia AUTHOR CONCLUSIONS · CPE 2010 ranking powerfully predicts HIV-1 reply in CSF during plasma viral suppression, but does not have the equal predictive duration in individuals with extracellular fluid about replicating virus. · This could be explained by approximately factors, specified as HIV medicate resistance, poor adhesion or intrathecal individual start that may compensation CPE in the context of virological lot and could lead to a classification 'tween plasm and CNS. · These results may have relevant implications for nonsubjective military science in condition to delimitate patients at higher risk of CSF/plasma discordant HIV-1 suppression and could be reclaimable for the clinicians to choose the more effective antiretroviral therapy for subsets of patients · Including neuroactive drugs in the c ART regimen could be advised in the group of patients with complete virological prevention in plasma in state to bully body process the HIV riposte in CSF and preserve CNS from neurocognitive and medicine disorders. HIV-1 replication in CSF despite viral suppression in state has been recommended as associated with neurocognitive impairment and neurological disease.
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Antiretroviral CNS Penetration-Effectiveness (CPE) 2010 ranking predicts CSF viral suppression only in patients with undetectable HIV-1 RNA in plasma

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HIV & AIDS Information :: Treating HIV throughout the body - Drugs that penetrate the brain

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Treating HIV in the head can be a challenge, since umteen antiretroviral drugs cannot cross the blood-brain barrier . Further, studies look to suggest that the amount of a specific drug that reaches the mental capacity can vary from person to person. Among the glycoside backward polymerase inhibitors (NRTIs) , AZT (zidovudine, Retrovir), 3TC (lamivudine, Epivir), d4T (stavudine, Zerit) and abacavir (Ziagen) wealthy person been shown to go in the blood-brain barrier.
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